HPV is the most common sexually transmitted infection globally, with over 200 strains. Among these, high-risk HPV strains (such as types 16 and 18) are associated with cervical cancer in women. All cervical cancers are caused by HPV infection, particularly strains 16 and 18, which account for at least 70% of cases. HPV vaccination is a powerful preventive measure, preventing 90% of cervical cancer cases. We conducted this research to determine the association between maternal HPV knowledge, religion, and the adoption of HPV vaccines for their Girl-Child in Nigeria. We conducted a cross-sectional survey in February 2024 among women with one or more girl-child between 9-14 in Jalingo, Taraba, Nigeria.

Methods: This community-based cross-sectional study was conducted among participants from Jalingo, the capital city of Taraba State. A convenient sampling method was utilized to recruit participants from major gathering points (the Open markets and other places where people gather and play). Data was collected from 413 participants using Google Forms, administered face-to-face by trained data collectors. Data analysis was conducted using SPSS version 28. Associations were determined using univariate and multivariate analysis.

Result: A statistical significance and positive association between HPV knowledge by the mother and acceptance of HPV vaccination for their child-girl, with 691% increase in the likelihood of adoption with a unit increase in HPV knowledge by the mother. No significant association was found between HPV vaccine adoption and the religion of the mother.

Conclusion: The introduction of the HPV vaccine in Nigeria represents a significant milestone in the fight against cervical cancer. Government and public health policymakers must improve awareness across the board. Policymakers must engage community leaders, schools, and healthcare providers to disseminate accurate information about HPV, Cervical cancer, and the role of vaccines as a preventive measure. A robust message will go a long way to create the desired end to cervical cancer in Nigeria