This study investigates the effect of marketing strategies specifically product, price, promotion, and place on the performance of Small and Medium Scale Enterprises (SMEs) in Kano State, Nigeria. Recognizing the pivotal role SMEs play in economic development, the research aims to determine how strategic marketing efforts influence business outcomes such as profitability, customer satisfaction, and market expansion. A survey research design was employed, with data collected from 393 SME operators across various sectors using structured questionnaires. Data were analyzed using descriptive statistics, Spearman’s correlation, and multiple regression techniques via SPSS version 20. The findings revealed that all four marketing strategies have significant positive effects on SME performance. Product strategy exhibited the strongest influence (β = 0.305, p < 0.01), followed by place (β = 0.276), price (β = 0.192), and promotion (β = 0.157). The regression model accounted for 53% of the variance in SME performance (R² = 0.530), indicating a strong explanatory power. The study concludes that the effective implementation of integrated marketing strategies is essential for improving SME performance. It recommends that SME operators focus on enhancing product quality, distribution efficiency, value-based pricing, and cost-effective promotional efforts. Despite limitations such as geographical scope and self-reported data, the study contributes significantly to the body of knowledge on SME marketing and provides a practical framework for marketing decision-making. It also suggests future research directions including regional comparisons and longitudinal studies for broader applicability.