This study examined the effectiveness of Strategic Intervention Material and Workbook Combined (SIM-WorC) in enhancing students’ academic performance in science. Using a pretest-posttest nonequivalent group design, the research involved 87 students—38 in the experimental group exposed to SIM-WorC and 49 in the control group taught through traditional methods. Statistical analyses using paired and independent sample t-tests revealed significant differences in pretest-posttest scores and gain scores, indicating that students who received SIM-WorC instruction showed marked improvement in learning outcomes compared to their peers. The findings underscore SIM-WorC’s potential to boost competency mastery and academic performance, demonstrating its value as a supplementary instructional tool. In light of these results, it is recommended that science educators integrate SIM-WorC into their teaching practices to reinforce student engagement and understanding. Additionally, school administrators should encourage the creation and effective use of such materials, and consider expanding the development and testing of SIM-WorC-based resources across other disciplines within the curriculum to support broader educational impact.