This study aimed to develop and validate “IT-SIBOL” (Interactive Thematic Station-Based Instruction for Biology Offline Learning), a PowerPoint-based instructional technology designed to enhance the delivery and comprehension of Grade 7 Biology topics under the K–12 Science Curriculum. The study utilized a Research and Development (R&D) design guided by the modified 4D Model of Thiagarajan et al. (1974), covering only the Define, Design, and Develop phases. A descriptive-quantitative approach was used to evaluate the content, instructional quality, and technical quality of the IT-SIBOL through expert validation. There are 17 IT-SIBOL lessons developed that consistently follow the same section format and instructional structure, using thematic, inquiry-based, station-based, and 5E instructional frameworks. Twenty (20) qualified validators, consisting of ten (10) Biology Validators and ten (10) IT validators. They hold Master’s or Doctorate degrees and possess extensive expertise in their respective fields, with at least five years of professional experience. This ensured a reliable and comprehensive validation. Content and instructional quality were assessed in terms of learning outcomes, face validity, lesson presentation, usefulness, and novelty, while technical quality covered multimedia design, interface, customizability, system controls, and hyperlinks. The findings revealed that validators confirmed that the initial version of the IT-SIBOL demonstrated strong approval on content and instructional quality, which indicates clear objectives, accurate content, relevant and well-organized lessons, innovative and strong usefulness. Moreover, the technical quality met excellent technical standards in design, interface, controls, and multimedia features. Therefore, the IT-SIBOL instructional technology is suitable, usable, and ready for pilot-testing in the classroom.