Entrepreneurship plays a crucial role in economic development through employment creation, innovation, poverty reduction, and income generation. Despite the growing number of entrepreneurs in Yobe State, Nigeria, many businesses experience failure due to insufficient access to finance, poor infrastructure, regulatory challenges, and limited entrepreneurial skills. Studies on the determinants of entrepreneurial choices have been widely researched, but the determinants among small and medium scale enterprises (SMSEs) have not been fully explored in Yobe state, Nigeria. This study attempts to explore the determinants of entrepreneurship among entrepreneurs in Yobe state, Nigeria. To achieve the objectives of this study, we employ logit regression and a sample of 270 entrepreneurs was selected from the three geo political zones in the state using random sampling method. Findings from the study reveal that start-up capital, access to finance, age, level of education, family background and government support and policies to have significantly influenced entrepreneurship among small and medium scale enterprises in Yobe state. Based on these findings, the study recommends that a coordinated policy approach that incorporate financial support, entrepreneurship education, government interventions and family based mentoring will help increase the number of entrepreneurs in Yobe state and Nigeria at large.