Antimicrobial resistance has necessitated the exploration of alternative therapeutic agents derived from natural products. This study evaluate the antibacterial efficacy of honey and ginger (Zingiber officinale) against throat-associated bacterial isolates, Staphylococcus aureus and Bacillus spp. Using standard microbiological techniques, bacterial isolates were obtained and identified from throat swabs. Antibacterial activity was assessed using agar well diffusion and broth micro dilution methods. Results demonstrated concentration-dependent inhibitory effects of both honey and ginger, with honey exhibiting greater antibacterial potency. The findings support the potential application of natural products as complementary antimicrobial agents.