This research is an exegetical study of Matthew 28:18-20 with the overall aim of studying its implication as it relates to contemporary issues facing missions today. The research was motivated by the numerous numbers of unsaved people the researcher saw on his visit to Loti mission field during an evangelistic outreach to the village where there is a mix of Egba and Zabarmarwa people. The village has only one church that is struggling to reach the large muslim Zabarmarwa and idolatrous populace of Egba descent despite its proximity to Abeokuta, a city where there are churches on almost all the streets. The study adopted the observational and unstructured interview method of the survey type to elicit response from a few respondents.  Findings revealed that several churches attempted to evangelize Loti but failed. Though a church exist in the village but her impact is not felt due to underfunding and poor oversight from the sending church. More so, they do not have enough missionary presence working among them to fulfill the great commission. The study concludes that there are numerous grounds to cover in the pursuit of the Great Commission especially among unreached people groups because churches have concentrated most of their efforts in reached places at the neglect of those places lacking sufficient presence of churches.  This study recommends that the church should make the Great Commission her priority and give all necessary support for those sent to unreached places among other necessary things.