This study aims to investigate the effects of technological innovation, management information systems (MIS), and entrepreneurship innovation on sustainable business performance among small and medium enterprises (SMEs) in Kano Metropolis, Nigeria. The study investigates the way these elements shape sustainability together to gain a full grasp of how innovation and information systems contribute to sustainability in emerging markets. Despite the recognized importance of innovation and information systems in achieving sustainable business outcomes, many SMEs in developing economies, particularly in Nigeria, struggle to integrate these elements effectively due to infrastructural, managerial, and socio-economic constraints. Only a small number of studies have been done in Kano Metropolis to study the relationship among technological innovation, MIS and entrepreneurship. As a result, it becomes difficult to design strategies and policies that use evidence and local understanding. Quantitative methods were used in this research by administering questionnaires to owners and managers of SMEs in Kano Metropolis. This approach was applied to guarantee that all sectors were fairly We were purposive with our strategy to guarantee variance in the composition of our focus group. Analysis with multiple regression was used to determine the separate and joint effects of the three innovation subscales on sustainable business performance. Results confirm that technological innovation, using MIS tools and entrepreneurial ideas all boost sustainable business performance. The impact of these variables is stronger when considered together than when considered by themselves. It was also shown that the way these issues connect to local settings and cultures plays a role in these relationships. The study recommends that SMEs in Kano should adopt an integrated innovation strategy that leverages technology, effective information systems, and entrepreneurial thinking. Policymakers should provide targeted support, such as digital infrastructure, capacity-building programs, and access to finance, to enable SMEs to harness these innovations sustainably. Besides, academic bodies and organizations working on development should form models that match the economic and social conditions in Nigerian cities.